My Bibliography

select

Leibler C, John S, Elsner RA, Thomas KB, Smita S, Joachim S, Levack RC, Callahan DJ, Gordon RA, Bastacky S, Fukui R, Miyake K, Gingras S, Nickerson KM, Shlomchik MJ. Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus. Nat Immunol. 2022 Oct;23(10):1457-1469. doi: 10.1038/s41590-022-01310-2. Epub 2022 Sep 23. PubMed PMID: 36151396; PubMed Central PMCID: PMC9561083.

select

Hartmeier PR, Kosanovich JL, Velankar KY, Armen-Luke J, Lipp MA, Gawalt ES, Giannoukakis N, Empey KM, Meng WS. Immune Cells Activating Biotin-Decorated PLGA Protein Carrier. Mol Pharm. 2022 Jul 4;19(7):2638-2650. doi: 10.1021/acs.molpharmaceut.2c00343. Epub 2022 May 27. PubMed PMID: 35621214; PubMed Central PMCID: PMC10105284.

select

Dadey RE, Grebinoski S, Zhang Q, Brunazzi EA, Burton A, Workman CJ, Vignali DAA. Regulatory T Cell-Derived TRAIL Is Not Required for Peripheral Tolerance. Immunohorizons. 2021 Jan 22;5(1):48-58. doi: 10.4049/immunohorizons.2000098. PubMed PMID: 33483333; PubMed Central PMCID: PMC8663370.

select

Weisel NM, Weisel FJ, Farber DL, Borghesi LA, Shen Y, Ma W, Luning Prak ET, Shlomchik MJ. Comprehensive analyses of B-cell compartments across the human body reveal novel subsets and a gut-resident memory phenotype. Blood. 2020 Dec 10;136(24):2774-2785. doi: 10.1182/blood.2019002782. PubMed PMID: 32750113; PubMed Central PMCID: PMC7731793.

select

Sedlacek AL, Younker TP, Zhou YJ, Borghesi L, Shcheglova T, Mandoiu II, Binder RJ. CD91 on dendritic cells governs immunosurveillance of nascent, emerging tumors. JCI Insight. 2019 Apr 4;4(7). doi: 10.1172/jci.insight.127239. eCollection 2019 Apr 4. PubMed PMID: 30944251; PubMed Central PMCID: PMC6483634.

select

Liu A, Chen M, Kumar R, Stefanovic-Racic M, O'Doherty RM, Ding Y, Jahnen-Dechent W, Borghesi L. Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4. Nat Commun. 2018 Feb 16;9(1):708. doi: 10.1038/s41467-018-03145-8. PubMed PMID: 29453396; PubMed Central PMCID: PMC5816016.

select

Balmert SC, Donahue C, Vu JR, Erdos G, Falo LD Jr, Little SR. In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis. J Control Release. 2017 Sep 10;261:223-233. doi: 10.1016/j.jconrel.2017.07.006. Epub 2017 Jul 8. PubMed PMID: 28694031; PubMed Central PMCID: PMC9169568.

select

McIlvried LA, Cruz JA, Borghesi LA, Gold MS. Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura. Cephalalgia. 2017 Jan;37(1):36-48. doi: 10.1177/0333102416637832. Epub 2016 Jul 11. PubMed PMID: 26970607; PubMed Central PMCID: PMC5023503.

select

Liu A, Wang Y, Ding Y, Baez I, Payne KJ, Borghesi L. Cutting Edge: Hematopoietic Stem Cell Expansion and Common Lymphoid Progenitor Depletion Require Hematopoietic-Derived, Cell-Autonomous TLR4 in a Model of Chronic Endotoxin. J Immunol. 2015 Sep 15;195(6):2524-8. doi: 10.4049/jimmunol.1501231. Epub 2015 Aug 14. PubMed PMID: 26276875; PubMed Central PMCID: PMC4561199.

select

McIlvried LA, Borghesi LA, Gold MS. Sex-, Stress-, and Sympathetic Post-Ganglionic Neuron-Dependent Changes in the Expression of Pro- and Anti-Inflammatory Mediators in Rat Dural Immune Cells. Headache. 2015 Jul-Aug;55(7):943-57. doi: 10.1111/head.12596. Epub 2015 Jun 30. PubMed PMID: 26126992; PubMed Central PMCID: PMC4514592.

select

Park KS, Bayles I, Szlachta-McGinn A, Paul J, Boiko J, Santos P, Liu J, Wang Z, Borghesi L, Milcarek C. Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. J Immunol. 2014 Nov 1;193(9):4663-74. doi: 10.4049/jimmunol.1401608. Epub 2014 Sep 19. PubMed PMID: 25238757; PubMed Central PMCID: PMC4201982.

select

Borghesi L. Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells. J Immunol. 2014 Sep 1;193(5):2053-8. doi: 10.4049/jimmunol.1400936. Review. PubMed PMID: 25128551; PubMed Central PMCID: PMC4135530.

select

Santos PM, Ding Y, Borghesi L. Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells. J Immunol. 2014 Jan 1;192(1):160-8. doi: 10.4049/jimmunol.1302502. Epub 2013 Nov 20. PubMed PMID: 24259504; PubMed Central PMCID: PMC3893818.

select

Boiko JR, Borghesi L. Hematopoiesis sculpted by pathogens: Toll-like receptors and inflammatory mediators directly activate stem cells. Cytokine. 2012 Jan;57(1):1-8. doi: 10.1016/j.cyto.2011.10.005. Epub 2011 Nov 12. Review. PubMed PMID: 22079335; PubMed Central PMCID: PMC3361504.

select

Santos P, Arumemi F, Park KS, Borghesi L, Milcarek C. Transcriptional and epigenetic regulation of B cell development. Immunol Res. 2011 Aug;50(2-3):105-12. doi: 10.1007/s12026-011-8225-y. Review. PubMed PMID: 21717070.

select

Kardava L, Yang Q, St Leger A, Foon KA, Lentzsch S, Vallejo AN, Milcarek C, Borghesi L. The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells. Int Immunol. 2011 Jun;23(6):375-84. doi: 10.1093/intimm/dxr027. Epub 2011 May 6. PubMed PMID: 21551245; PubMed Central PMCID: PMC3103389.

select

Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, Zhang Q, Humphrey MB, Yang Q, Borghesi LA, Kincade PW. Chronic exposure to a TLR ligand injures hematopoietic stem cells. J Immunol. 2011 May 1;186(9):5367-75. doi: 10.4049/jimmunol.1003438. Epub 2011 Mar 25. PubMed PMID: 21441445; PubMed Central PMCID: PMC3086167.

select

Hockert KJ, Martincic K, Mendis-Handagama SM, Borghesi LA, Milcarek C, Dass B, MacDonald CC. Spermatogenetic but not immunological defects in mice lacking the τCstF-64 polyadenylation protein. J Reprod Immunol. 2011 Apr;89(1):26-37. doi: 10.1016/j.jri.2011.01.018. Epub 2011 Apr 13. PubMed PMID: 21489638; PubMed Central PMCID: PMC3081895.

select

Santos PM, Borghesi L. Molecular resolution of the B cell landscape. Curr Opin Immunol. 2011 Apr;23(2):163-70. doi: 10.1016/j.coi.2010.11.014. Epub 2011 Jan 12. Review. PubMed PMID: 21236654; PubMed Central PMCID: PMC3073704.

select

Yang Q, Esplin B, Borghesi L. E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction. Blood. 2011 Mar 31;117(13):3529-38. doi: 10.1182/blood-2010-07-297689. Epub 2011 Jan 27. PubMed PMID: 21273306; PubMed Central PMCID: PMC3072876.

select

Kuhrt D, Faith S, Hattemer A, Leone A, Sodora D, Picker L, Borghesi L, Cole KS. Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation. J Immunol Methods. 2011 Jan 5;363(2):166-76. doi: 10.1016/j.jim.2010.09.017. Epub 2010 Sep 24. PubMed PMID: 20875419; PubMed Central PMCID: PMC3357916.

select

Pal R, Janz M, Galson DL, Gries M, Li S, Jöhrens K, Anagnostopoulos I, Dörken B, Mapara MY, Borghesi L, Kardava L, Roodman GD, Milcarek C, Lentzsch S. C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells. Blood. 2009 Oct 29;114(18):3890-8. doi: 10.1182/blood-2009-01-201111. Epub 2009 Aug 28. PubMed PMID: 19717648; PubMed Central PMCID: PMC2773489.

select

Martincic K, Alkan SA, Cheatle A, Borghesi L, Milcarek C. Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nat Immunol. 2009 Oct;10(10):1102-9. doi: 10.1038/ni.1786. Epub 2009 Sep 13. PubMed PMID: 19749764; PubMed Central PMCID: PMC2771556.

select

Vallejo AN, Michel JJ, Bale LK, Lemster BH, Borghesi L, Conover CA. Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11252-7. doi: 10.1073/pnas.0807025106. Epub 2009 Jun 22. PubMed PMID: 19549878; PubMed Central PMCID: PMC2700140.

select

Esplin BL, Welner RS, Zhang Q, Borghesi LA, Kincade PW. A differentiation pathway for B1 cells in adult bone marrow. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5773-8. doi: 10.1073/pnas.0811632106. Epub 2009 Mar 23. PubMed PMID: 19307589; PubMed Central PMCID: PMC2666989.

select

Borghesi L. Obama must match science rhetoric with action. Nature. 2009 Jan 1;457(7225):26. doi: 10.1038/457026a. PubMed PMID: 19122619.

select

Welner RS, Pelayo R, Nagai Y, Garrett KP, Wuest TR, Carr DJ, Borghesi LA, Farrar MA, Kincade PW. Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood. 2008 Nov 1;112(9):3753-61. doi: 10.1182/blood-2008-04-151506. Epub 2008 Jun 13. PubMed PMID: 18552210; PubMed Central PMCID: PMC2572801.

select

Yang Q, Kardava L, St Leger A, Martincic K, Varnum-Finney B, Bernstein ID, Milcarek C, Borghesi L. E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J Immunol. 2008 Nov 1;181(9):5885-94. doi: 10.4049/jimmunol.181.9.5885. PubMed PMID: 18941177; PubMed Central PMCID: PMC2597624.

select

Pilbeam K, Basse P, Brossay L, Vujanovic N, Gerstein R, Vallejo AN, Borghesi L. The ontogeny and fate of NK cells marked by permanent DNA rearrangements. J Immunol. 2008 Feb 1;180(3):1432-41. doi: 10.4049/jimmunol.180.3.1432. PubMed PMID: 18209038; PubMed Central PMCID: PMC4465768.

select

Borghesi L, Milcarek C. Innate versus adaptive immunity: a paradigm past its prime?. Cancer Res. 2007 May 1;67(9):3989-93. doi: 10.1158/0008-5472.CAN-07-0182. Review. PubMed PMID: 17483307.

select

Borghesi L, Milcarek C. From B cell to plasma cell: regulation of V(D)J recombination and antibody secretion. Immunol Res. 2006;36(1-3):27-32. doi: 10.1385/IR:36:1:27. Review. PubMed PMID: 17337763.

select

Borghesi L, Aites J, Nelson S, Lefterov P, James P, Gerstein R. E47 is required for V(D)J recombinase activity in common lymphoid progenitors. J Exp Med. 2005 Dec 19;202(12):1669-77. doi: 10.1084/jem.20051190. PubMed PMID: 16365147; PubMed Central PMCID: PMC2212960.

select

Labrie JE 3rd, Borghesi L, Gerstein RM. Bone marrow microenvironmental changes in aged mice compromise V(D)J recombinase activity and B cell generation. Semin Immunol. 2005 Oct;17(5):347-55. doi: 10.1016/j.smim.2005.05.012. Review. PubMed PMID: 15963731.

select

Borghesi L, Hsu LY, Miller JP, Anderson M, Herzenberg L, Herzenberg L, Schlissel MS, Allman D, Gerstein RM. B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J Exp Med. 2004 Feb 16;199(4):491-502. doi: 10.1084/jem.20031800. Epub 2004 Feb 9. PubMed PMID: 14769852; PubMed Central PMCID: PMC2211824.

select

Borghesi L, Gerstein RM. Developmental separation of V(D)J recombinase expression and initiation of IgH recombination in B lineage progenitors in vivo. J Exp Med. 2004 Feb 16;199(4):483-9. doi: 10.1084/jem.20031802. Epub 2004 Feb 9. PubMed PMID: 14769853; PubMed Central PMCID: PMC2211822.

select

Borghesi LA, Yamashita Y, Kincade PW. Heparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis. Blood. 1999 Jan 1;93(1):140-8. PubMed PMID: 9864155.

select

Kincade PW, Yamashita Y, Borghesi L, Medina K, Oritani K. Blood cell precursors in context. Composition of the bone marrow microenvironment that supports B lymphopoiesis. Vox Sang. 1998;74 Suppl 2:265-8. doi: 10.1111/j.1423-0410.1998.tb05430.x. Review. PubMed PMID: 9704455.

select

Kincade PW, Oritani K, Zheng Z, Borghesi L, Smithson G, Yamashita Y. Cell interaction molecules utilized in bone marrow. Cell Adhes Commun. 1998;6(2-3):211-5. doi: 10.3109/15419069809004476. Review. PubMed PMID: 9823471.

select

Borghesi LA, Smithson G, Kincade PW. Stromal cell modulation of negative regulatory signals that influence apoptosis and proliferation of B lineage lymphocytes. J Immunol. 1997 Nov 1;159(9):4171-9. PubMed PMID: 9379010.

select

Borghesi LA, Lynes MA. Nonprotective effects of extracellular metallothionein. Toxicol Appl Pharmacol. 1996 Jul;139(1):6-14. doi: 10.1006/taap.1996.0137. PubMed PMID: 8685909.

select

Borghesi LA, Lynes MA. Stress proteins as agents of immunological change: some lessons from metallothionein. Cell Stress Chaperones. 1996 Jun;1(2):99-108. doi: 10.1379/1466-1268(1996)001<0099:spaaoi>2.3.co;2. Review. PubMed PMID: 9222595; PubMed Central PMCID: PMC248461.

select

Youn J, Borghesi LA, Olson EA, Lynes MA. Immunomodulatory activities of extracellular metallothionein. II. Effects on macrophage functions. J Toxicol Environ Health. 1995 Aug;45(4):397-413. doi: 10.1080/15287399509532004. PubMed PMID: 7643428.

select

Lynes MA, Borghesi LA, Youn J, Olson EA. Immunomodulatory activities of extracellular metallothionein. I. Metallothionein effects on antibody production. Toxicology. 1993 Dec 31;85(2-3):161-77. doi: 10.1016/0300-483x(93)90040-y. PubMed PMID: 8303711.