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CDC TECH LIFE PODCAST

Episode 40 of the CDC Tech Life Podcast features Steve Dykes, Executive Director of Charleston County Economic Development

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Episode 40 of the CDC Tech Life Podcast features Steve Dykes, Executive Director for the Charleston County Economic Development Department. Steve walks us through over 30 years of economic growth in Charleston County and how the region is poised for more great things in the future.

This episode is sponsored by the City of Charleston. The City of Charleston is pleased to support the Charleston Digital Corridor with its mission to foster innovation and entrepreneurship.

FEATURED NEWS

Avicenna Introduces Machine Learning-Enhanced Medicinal Chemistry Platform to Accelerate the Last Mile of Small Molecule Drug Discovery

Avicenna Biosciences today introduced an extension to its machine learning (ML) technology platform to enhance medicinal chemistry and expedite clinical-stage drug discovery. The company has raised $14.5 million in funding to date, with DCVC Bio leading its 2022 seed round, and this month published a paper in the peer-reviewed Journal of Chemical Information and Modeling. Co-authored with researchers from Schrödinger and Microsoft Research AI4Science, the paper outlines how combining Schrödinger's physics-based methods with Avicenna's novel ML methods can make the lead-to-drug optimization phase of small molecule drug discovery faster, less expensive and more successful – particularly when it comes to engineering potency and selectivity against a potential biological target.

"We're accustomed to hearing scientific success stories, but the countless failures that happen along the way often get overlooked. In medicinal chemistry especially, failure is prevalent. It can require hundreds of millions of dollars across many clinical attempts to bridge the complex gap from chemistry and biology to medicine, and successfully develop an approved drug," said Dr. Thomas Kaiser, co-founder and Chief Scientific Officer at Avicenna. "Avicenna is applying novel ML methods to navigate the unknowns in medicinal chemistry and design around them. Our methods allow a drug design team to learn from years of failure and optimize against validated targets more efficiently. We're making the most critical phase of drug design –- the last mile of drug discovery –- substantially faster and more cost effective."

Technology Applications and Results

Avicenna is leveraging its technology to develop its own therapeutic programs, with an initial focus on neurodegenerative diseases. For example, Rho kinase (ROCK) inhibitors demonstrate potential in neurodegeneration and metabolic diseases. However, designing an orally dosed, central nervous system-penetrant ROCK inhibitor has proved extremely difficult. Fasudil, a promising ROCK inhibitor currently in Phase 2 clinical trials, must be dosed intravenously twice daily, precluding its use in illnesses like chronic kidney disease or neurodegeneration. To overcome these challenges, Avicenna has initiated its own ROCK Inhibitor Program. Using its novel ML technology to identify drug-like compounds with desired pharmacokinetic properties, the company has already achieved:

  • Faster Timelines: 9 months from idea to in vivo proof of concept
  • Reduced Costs: $220,000 from concept to initiation of Investigational New Drug (IND)-enabling studies
  • Better Therapeutics:__Two development candidates discovered while only synthesizing 11 total compounds

Research Paper Implications

"Creating new medicines and safely delivering them to the people who need them is incredibly difficult and full of risk. Avicenna is working to make drug discovery straightforward and fast by creating new algorithms to identify molecules with ideal drug-like properties," said Dr. John Hamer, Managing Partner at DCVC Bio. "Avicenna's collaborative research with Schrödinger and Microsoft demonstrates how a physics-based augmentation of ML requires just tens of molecules to optimize small molecules against a new drug target, as opposed to thousands. We couldn't be more excited to support this potentially game-changing biotechnology company as it scales to its next stage of growth."

Titled "FEP-Augmentation as a Means to Solve Data Paucity Problems for Machine Learning in Chemical Biology," Avicenna, Schrödinger, and Microsoft's newly published paper describes how to use physics-based methods such as Schrödinger's free energy perturbation technology, FEP+, to generate virtual data, which can be used to augment the sparse data sets commonly found in early medicinal chemistry optimization. These augmented datasets can be used for ML training where it was previously impossible to train without the disclosed approach. The augmentation is comparably informative for ML training as going through the effort and expense of making and testing the needed compounds. Ultimately, this allows an early-stage discovery team to access ML which can then quickly query millions of lead-like compounds and identify promising leads for drug development. The paper outlines the key mechanistic considerations for augmenting such data sets and lays the groundwork for implementation, demonstrating that an initial series of 10-20 related compounds, accompanied by 3D structures co-resolved with a small set of ligands, can serve as an accelerated foundation for lead optimization.

The research shows that combining FEP+ with ML can accelerate the hit-to-lead phase of drug discovery, which can generate profound implications, including:

  • Shorten the time spent in hit-to-lead optimization
  • Significant reduction in synthetic effort

Team and Partnership Opportunities

The Avicenna team's collective background in mathematics, chemistry and medicine brings a uniquely comprehensive perspective to their core discipline of medicinal chemistry. Co-founders Drs. Kaiser and Pieter Burger met while working within theLiotta Research Group at Emory University. The group is well known for its successes in drug development across virology, oncology and neurology, creating more than 20 FDA-approved therapeutics. As a synthetic organic chemist, Dr. Kaiser led the Liotta antivirals group, and as a structural bioinformaticist, Dr. Burger led its computational group.

In addition to developing its own therapeutic programs, Avicenna partners with clinical-stage biotech startups and major pharmaceutical organizations to optimize their drug discovery campaigns and maximize risk-return profiles, easily fitting into partners' existing chemistry workflows. For more information on Avicenna and its technology platform or to inquire about partnership opportunities, visit www.avicenna-bio.com.

About Avicenna Biosciences

Founded in 2020, Avicenna is on a mission to solve the intractable drug design challenges that previously stopped drug candidates in their tracks. The company's machine learning-driven medicinal chemistry platform makes lead-to-drug optimization faster, cheaper and more successful – transforming sub-optimal clinical candidates into life-saving drugs. Avicenna is backed by DCVC Bio, with Entrepreneur-in-Residence Christopher S. Meldrum having joined the Company as President and CEO. For more information, visit www.avicenna-bio.com and follow the company on LinkedIn.

Comcast Lift Zone Ribbon Cutting

Comcast Launches WiFi-Connected “Lift Zone” in Partnership with the Charleston Digital Corridor Learning Center

Comcast announced today the opening of its newest Xfinity WiFi- connected "Lift Zone" at the Charleston Digital Corridor (CDC) Learning Center, located inside the Charleston Tech Center, at 997 Morrison Drive, Suite 200 in Charleston. Lift Zones are safe spaces where communities can learn digital skills and pursue academic, professional and personal advancement.

Comcast also announced a $25,000 grant for the development and promotion of the CDC's Learning Center–the home of the Lift Zone. Over the last four years, Comcast has donated more than $80,000 to the CDC to support their mission of improving economic mobility in Charleston through digital skills training.

"We appreciate Comcast's longstanding dedication in support of Charleston's tech economy," said Ernest Andrade, Executive Director at Charleston Digital Corridor. "Comcast's Lift Zone designation at the CDC Learning Center is sure to have an impact on Charleston residents as they participate in much needed, meaningful digital literacy classes."

Additionally, Comcast donated 25 laptops to students at C.E. Williams Middle School who will attend the CDC Learning Center's "ChatGPT for Students" class.

"Comcast's commitment to Charleston's workforce readiness over the years has had an enormous impact on our community," said Charleston Mayor William S. Cogswell Jr. "I am honored to celebrate with Comcast today as they commemorate the opening of a valuable Lift Zone at Charleston Digital Corridor's Learning Center."

Lift Zones are part of a larger multiyear plan by Comcast to support community-organization based WiFi at more than 1,250 Lift Zones throughout the country – including South Carolina. Lift Zones are also an extension of the company's longstanding commitment to help connect families to the internet and provide resources to help them take advantage of educational opportunities and the digital economy.

"Comcast remains committed to bridging the digital divide by providing free, robust WiFi access through its Lift Zone initiative," said Mike McArdle, Comcast Regional Senior Vice President. "We are excited to team up with the Charleston Digital Corridor to offer a safe place where local students and families have access to online educational and life resources that are so critical."

Lift Zones complement Comcast's Internet Essentials program, the nation's largest and most successful private-sector low-income broadband adoption program. For more than a decade, Comcast has worked with trusted community partners, businesses and government to help millions of households connect to the Internet and the technology they need to participate in the digital world.

Since launching in 2011, Internet Essentials has connected more than 10 million people to the Internet at home, many for the very first time.

MUSC Chief Innovation Officer Jesse Goodwin, Ph.D

Blue Sky Labs Launches MUSC Innovation District In Charleston

The Medical University of South Carolina is preparing to welcome innovators to a retooled campus building that offers lab space to people with great ideas that need room for growth. It's the beginning of an innovation district that MUSC's president has called a generational opportunity.

The location of that beginning is a building on Calhoun Street in a former College of Pharmacy site. It's now home to Blue Sky Labs – a place for scientists and other experts who want to hone their creations, test new concepts and share space and ideas with fellow innovators. The long-term plan is for other locations to follow.

Blue Sky Labs is still in the process of getting up and running. But there's no question that it's an important step toward the ultimate goal: a district where, in the words of MUSC President David Cole, M.D., "universities, corporations, manufacturers, dreamers and philanthropists come together to create a new level of what is possible."

Jesse Goodwin, MUSC's chief innovation officer, is leading the effort and will be based in the pioneering Blue Sky building. "It is a physical demonstration of MUSC's commitment to innovation and entrepreneurship and fostering that culture among its faculty and staff."

She said cultivating innovation is one of MUSC's core commitments. "Why is now the right time? We are at an inflection point as an organization and as a region where we have enough groundswell momentum that it's time to double down on our efforts if we really want to move the needle and have the type of impact that I think MUSC is poised to have."

Building momentum

Poised, because MUSC has already developed multiple options for entrepreneurs who would benefit from institutional support, including:

  • The Zucker Institute for Innovation Commercialization, which helps MUSC innovators who want to start companies.
  • MUSC Health Solutions, which works within MUSC Health to validate pain points, conduct market research, develop build/buy/partner recommendations, and craft business cases for digital solutions.
  • Goodwin's Office of Innovation, which works to build a culture of innovation by supporting new ideas generation through programs, funding, and pilot projects.

MUSC also has multiple entrepreneurial success stories. Case in point: QuicksortRx, started by a former network engineer and former pharmacist at MUSC. It helps hospitals make better pharmacy buying decisions. It's been so successful that it's moving into bigger digs and getting ready to hire more than three dozen new employees.

Other companies started by current and former MUSC employees include GlycoPath, which focuses on biomarker research; Leukogene Therapeutics, an early-stage oncology drug discovery company; and FibroTherapeutics, which is developing treatments for diseases involving organ fibrosis and vascular leakage.

Blue Sky Labs' Role

Those success stories show there's already a supportive environment at MUSC and in Charleston for entrepreneurs. Goodwin said Blue Sky Labs will build on that.

"We're not trying to replace any of the existing entrepreneurial spaces like The Harbor Entrepreneur Center or the Digital Corridor. I think they're wonderful. This is a supplement to those."

An important distinction: "None of those existing spaces has lab space. This new MUSC space does," Goodwin said.

"So if you're a biotech company that needs a lab, until now, there was no place for you to go except for the South Carolina Research Authority incubator that's on the peninsula," Goodwin said.

"And that's almost always fully occupied. So SCRA is supportive as well. This is a supplement to support life sciences in the region. It's not a competition to the existing spaces. It can be complementary. Someone could have an office over in The Harbor and run their lab here."

And that would be perfectly fine with Goodwin. She sees MUSC's role as going well beyond teaching students and healing patients. She said the academic medical center also has an eye on the future. "I think it's our obligation to foster and support innovation."

Blue Sky Labs will be a part of that. Named for the concept that creativity doesn't have to be constrained by what we already know, Blue Sky Labs is part of MUSC's focus on the pursuit of knowledge that can change lives for the better. Its tag line is "Life changing ideas made real."

That concept has the potential to help transform part of the Charleston peninsula. MUSC's president put his vision of the innovation district this way. "Imagine an environment where people can see, feel and touch our future's potential. It is a place where innovation thrives, new and creative ideas are nurtured and others will come to seek expertise, provide their knowledge and resources and set the pace for economic growth."

Episode 39 of the CDC Tech Life Podcast features Edwin Goutier, CEO of Charleston SC-based Technology Startup - Launchpath.

Episode 39 of the CDC Tech Life Podcast features Edwin Goutier, CEO of Charleston SC-based Technology Startup Launchpath. Edwin talks about how Launchpath is unlocking innovation for its corporate customers and why they are now shifting their focus to the Non-Profit Sector.

This episode is sponsored by Charleston County Economic Development Department. They're dedicated to recruiting new business, growing existing industry and improving Charleston's business climate.

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Episode 38 of the CDC Tech Life Podcast features Shannon Caulk, co-founder and COO of Charleston SC-based Fintech Startup - Spendly

Episode 38 of the CDC Tech Life Podcast features Shannon Caulk, co-founder and COO of Charleston SC-based Fintech Startup Spendly. Shannon shares how her passion for UX sparked her pursuit of entrepreneurship and how Spendly is working with Payment and Insurance providers and making it easier and more affordable for small businesses to get the business services that they need.

This episode is sponsored by Charleston County Economic Development Department. They're dedicated to recruiting new business, growing existing industry and improving Charleston's business climate.

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Portside Technology Expands Footprint at The Charleston Tech Center

Portside Technology is pleased to announce the expansion of their corporate headquarters office at the Charleston Tech Center to facilitate their robust growth. The self-funded company, launched in 2020, has grown into a team of over 40 seasoned technologists providing professional services and technology infrastructure solutions to small and mid-size businesses with a national and global footprint.

Portside Technology mentioned Charleston's livability, air service, availability of technical talent, and robust support for local tech companies as key factors in their decision to expand their footprint in the region.

"Our ability to expand within the Charleston Tech Center while remaining in close proximity to the Charleston Digital Corridor is ideal for our fast-growing company", said Portside Technology Founder & CEO, Zach McNamara.

The Charleston Tech Center, a new Class A tech-focused office building was designed and developed to accommodate the business dynamics of higher-wage tech companies in Charleston by ensuring the seamless transition from a solo entrepreneur to as many as 100 employees at the building.

"We are pleased to support the expansion of Portside Technology at the Charleston Tech Center," said Managing Partner, John Hand. "Their expansion, like other tech companies that have expanded at the building, once again validates our win-win business model," he added.

"We are excited to witness the explosive growth of our member and resident, Portside Technology, at the Charleston Tech Center and honored to facilitate their expansion within the building," said Charleston Digital Corridor Director, Ernest Andrade.

Dr. Tyler Horan Joins Topline as Founding CTO Following Pre-Seed Funding Round

Topline, the creator of the world's largest public professional index with over 700 million professionals indexed worldwide, is excited to announce the addition of Dr. Tyler Horan as its Founding Chief Technology Officer (CTO). This announcement comes in the wake of Topline closing it's pre-seed investment round, with participation from leading venture firms including Bain Capital Ventures, Flex Capital, Sweet Spot Capital, and Mission8 Ventures.

A distinguished leader in the field of Computational Social Science and Machine Learning, Dr. Horan's extensive research has delved deep into social networks, online communities, and online marketplaces, making him an unparalleled asset to the Topline team. His tenure as a technical leader at Handshake and Bright Software, combined with a Ph.D. in Sociology from the New School for Social Research, has equipped him with a unique perspective on data analytics, social dynamics and machine learning.

The pre-seed investment round, which saw participation from industry-leading firms such as Bain Capital Ventures, Sweet Spot Capital, Flex Capital, and Mission8 Ventures, along with numerous angel investors, underscores the market's anticipation for Topline's innovative solutions. This funding is a testament to Topline's commitment to revolutionizing how professionals can flourish in the era of work ahead.

In the near future, Topline is set to launch the Topline Index, a groundbreaking tool anticipated to transform the landscape of work by providing unparalleled insights into professional trends and behaviors. Additionally, the expansion of the Topline Operating System [Topline OS ][1]promises to equip businesses with the tools necessary for navigating the complexities of the modern professional environment.

"Alex Skatell, CEO of Topline, commented, "With Tyler leading our technological vision, Topline is poised to unlock new opportunities to help the best professionals win. His deep expertise in machine learning, people data, and digital communities aligns perfectly with our mission to provide deep, actionable insights into the professional world."

Dr. Horan expressed his excitement about the role, stating, "Joining Topline offers a unique opportunity to apply my research in a way that directly impacts the global professional landscape. I am excited to lead the development of tech that not only increases small business' bottom line but also nurture a deeper understanding of professional networks and communities."

About Topline:

We believe in a world where every skilled professional has the opportunity to thrive independently. With over 70 million people in the United States already providing independent services, and billions of work opportunities becoming available to talent worldwide we're at the forefront of a booming market that's redefining the workforce.

Our mission is simple: We're building a future where the best professionals win. We do that in 3 ways: Remove the friction of hiring professionals. Provide tools to help the best professionals stand out. Offer trusted information on service providers and firms.

We're not just talking about a platform; we're building the world's largest public index of professionals, with over 700 Million Global Professionals and growing along with Topline OS tools to level the playing field for independent providers and growing firms

[1]: https://topline.com/os-operating-system/)

Upcoming Classes & Events

NEXT CDCLC CLASS
May 15, 9AM - 10:30AM

The Entrepreneurs Legal Essentials

There is a saying in business - plan for the best but prepare for the worst. Failing to properly plan for business growth can could be very expensive to address later. This class taught by a vetted legal professional is designed to help entrepreneurs avoid the legal pitfalls that so many start-ups and growing businesses encounter.

CDC LEARNING CENTER
May 15, 9AM - 10:30AM

The Entrepreneurs Legal Essentials

There is a saying in business - plan for the best but prepare for the worst. Failing to properly plan for business growth can could be very expensive to address later. This class taught by a vetted legal professional is designed to help entrepreneurs avoid the legal pitfalls that so many start-ups and growing businesses encounter.

EVENT
May 15, 9AM - 7PM

AO Summit

Join us in Mount Pleasant, South Carolina for AO Summit, a one-day event  serving as a meeting point to share and learn all things related to AO, the hyper parallel computer! The AO summit will bring together builders, community members, and enthusiasts to share, learn, and connect with each other to grow the ecosystem and make some fun memories in one of America's most beautiful cities! Learn more and register HERE.

CDC LEARNING CENTER
May 16, 5:30PM - 7:30PM

Charleston Data Science Meetup

In this talk, we'll break down the end-to-end process from ideation to producing a trained algorithm that can hear and interpret text being written. In the talk, we'll see how well an algorithm can interpret the sound of written data live.

CDC LEARNING CENTER
May 21, 6PM - 7:30PM

Charleston AWS Meetup

Join the Charleston AWS Meetup with AWS enthusiast, Jack Heaton. In this months talk, we will dive into a quick hands on with Amplify Gen2, AWS's new code-first developer experience.

CDC LEARNING CENTER
May 22, 9AM - 1PM

The Entrepreneurs Sales Playbook

Many entrepreneurs believe "if we build it, they will come". The reality is, selling well really matters when it comes to achieving sustainable double-digit revenue growth. If your company's revenue growth is stagnating or you aren't winning enough deals against your competition, this program will give you a whole new way of looking at your approach to B2B sales.

EVENT
May 30, 4PM - 6PM

Beyond the Hype: Practical Steps and Risk Mitigation for AI Integration

Join us to learn about Artificial Intelligence (AI) integration at our first InnoVision Forum for 2024, "Beyond the Hype." InnoVision Chair, Attorney Hunter Freeman will lead the panel discussion. We'll delve into the practical steps and essential risk reduction strategies for successful AI implementation, covering topics such as data privacy concerns, ethical considerations, and techniques to safeguard your business from unintended consequences and legal liability. Our panelists have navigated the complexities of AI integration firsthand. Learn more and register HERE. 

CDC LEARNING CENTER
Jun 19, 2PM - 4PM

Introduction to ChatGPT

The "Introduction to ChatGPT" class offers an insightful journey into the capabilities, applications, and underlying principles of ChatGPT, a cutting-edge large language model (LLM) developed by OpenAI. This course provides participants with a foundational understanding of how ChatGPT works and equips them with practical knowledge to interact effectively with the model.

CDC LEARNING CENTER
Jul 17, 9AM - 11AM

Next Level ChatGPT

So, you've been using ChatGPT and want to go further? This class is designed to level up your beginner skills and understand how to get the most out of this new technology.

CDC LEARNING CENTER
Aug 14, 9AM - 11AM

ChatGPT for Business

Unlock the power of generative AI! Join our workshop tailored for Executives and Entrepreneurs looking to leverage cutting-edge technology. Discover how generative AI, with reported productivity gains of 20-30%, can transform your business. While ChatGPT takes center stage, we'll also explore other exciting options.

CDC LEARNING CENTER
Sep 24, 2PM - 4PM

The Tech Investor's Playbook

Interested in learning how to make money in tech stocks? Technology stocks comprise 43% of the weight of the S&P 500. 8 of America's 10 largest companies by market cap are tech firms.

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