International Harmonization of Nomenclature and Diagnostic Criteria (INHAND):          Nonproliferative and Proliferative Lesions of the Rabbit

Alys E Bradley; Lyn Miller Wancket; Matthias Rinke; Margarita M Gruebbel; Brett H. Saladino; Kenneth Schafer; Osamu Katsuta; Begonya Garcia; Franck Chanut; Katherine Hughes; Keith Nelson; Lauren Himmel; Elizabeth McInnes; Adrienne Schucker; Kazuyuki Uchida

doi:10.1293/tox.34.183S

Review

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

Alys E Bradley, Lyn Miller Wancket, Matthias Rinke, Margarita M Gruebbel, Brett H. Saladino, Kenneth Schafer, Osamu Katsuta, Begonya Garcia, Franck Chanut, Katherine Hughes, Keith Nelson, Lauren Himmel, Elizabeth McInnes, Adrienne Schucker, Kazuyuki Uchida

Author information

Alys E Bradley
Charles River Laboratories Edinburgh Ltd, Tranent, Scotland, UK
Lyn Miller Wancket
Charles River Laboratories, Durham, NC, USA
Matthias Rinke
formerly Bayer AG, Germany
Margarita M Gruebbel
Experimental Pathology Laboratories Inc, Research Triangle Park, NC, USA
Brett H. Saladino
StageBio, Mason, OH, USA
Kenneth Schafer
Greenfield Pathology Services, Inc. Greenfield, IN, USA
Osamu Katsuta
Santen Pharmaceutical Co. Ltd, Nara, Japan
Begonya Garcia
Charles River Laboratories Edinburgh Ltd, Tranent, Scotland, UK
Franck Chanut
Sanofi, 1 Avenue Pierre Brosselette, 91380 Chilly-Mazarin, France
Katherine Hughes
University of Cambridge, UK
Keith Nelson
Charles River Laboratories, Mattawan, MI, USA
Lauren Himmel
Vanderbilt University Medical Center, Nashville, TN, USA
Elizabeth McInnes
Syngenta, Jealotts Hill, Bracknell, Berkshire, UK, UK
Adrienne Schucker
American Preclinical Services, LLC, 8945 Evergreen Blvd, Minneapolis, MN 55433
Kazuyuki Uchida
The University of Tokyo, Tokyo, Japan

Keywords: rabbit, pathology, toxicopathology, nomenclature, background findings, INHAND, New Zealand

JOURNAL OPEN ACCESS

2021 Volume 34 Issue 3_Suppl Pages 183S-292S

DOI https://doi.org/10.1293/tox.34.183S

Details

Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the laboratory rabbit used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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