Oral Fluconazole in Pregnancy and Risk of Stillbirth and Neonatal Death

Björn Pasternak; Viktor Wintzell; Kari Furu; Anders Engeland; Martin Neovius; Olof Stephansson

doi:10.1001/jama.2018.6237

Oral Fluconazole in Pregnancy and Risk of Stillbirth and Neonatal Death

JAMA. 2018 Jun 12;319(22):2333-2335. doi: 10.1001/jama.2018.6237.

Authors

Björn Pasternak¹, Viktor Wintzell¹, Kari Furu², Anders Engeland², Martin Neovius¹, Olof Stephansson¹

Affiliations

¹ Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
² Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Oslo, Norway.

Abstract

This pharmacoepidemiology study uses Swedish and Norwegian registry data to investigate associations between fluconazole use during pregnancy and subsequent stillbirth and neonatal death.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Antifungal Agents / administration & dosage
Antifungal Agents / adverse effects*
Cohort Studies
Female
Fluconazole / administration & dosage
Fluconazole / adverse effects*
Humans
Infant, Newborn
Perinatal Death / etiology*
Pregnancy
Pregnancy Complications, Infectious / drug therapy
Propensity Score
Regression Analysis
Stillbirth / epidemiology*

Substances

Antifungal Agents
Fluconazole